An article published in the journal “Nature Communications” reports the verification of the consistency of two datasets containing information on the application of a CRISPR-Cas9 system to obtain genetic modifications of cancer cells within research on their genetic alterations. A team of researchers from the Wellcome Sanger Institute and the Broad Institute of MIT and Harvard compared the consistency of the two datasets, independently verifying the methodology and findings and validating 725 cancer models covering 25 different types of cancer. This is very useful information to understand the importance of the various genes in the survival of cancer cells and to create targeted treatments in a strategic collaboration called Cancer Dependency Map (Cancer DepMap).