Earth Abides by George R. Stewart
The novel “Earth Abides” by George R. Stewart was published for the first time in 1949. It won the International Fantasy Award.
Isherwood “Ish” Williams is working on his graduate thesis in the mountains when he gets bitten by a rattlesnake. He manages to get rid of most of the poison but spends days unwell, even from what appears to be an illness unrelated to the poisoning. When he gets strong enough again, he travels to the nearest town and finds it deserted, only the first evidence of a mass death caused by an unknown disease.
Ish seeks out other survivors, who are few in number and not always friendly, sometimes in a severely altered state of mind. After touring the now almost completely depopulated USA, he returns to California and decides to settle in the area. He finds a woman, Emma, and the two of them decide to live together. Over time, they find a few other survivors with whom to form a small community but what can be the future of humanity?